pilocide™ antibacterial skin injections
Scientific Evidence
Peer-Reviewed Articles
Clinical trials utilizing subcutaneous antibiotic injections as surgical prophylaxis have produced robust evidence. The methodology has been utilized worldwide among physicians for over thirty years. Efficacy and data have been demonstrated in reducing surgical site infections in dermatologic and general surgery. Clinical trials are warranted for pilocide™ injection treatments as surgical prophylaxis and postoperative treatment.
pilocide™ surgical prophylaxis
Effect of Microdoses of Incisional Antibiotics on the Rate of Surgical Site Infections in Skin Cancer Surgery: A Randomized Clinical Trial
Summary: Prophylactic antibiotic treatments for surgical incisions are needed that are effective, rapid-acting, safe, and tolerable. This clinical study evaluated using intra-incisional antibiotics for surgical prophylaxis in skin cancer surgery. The study was a double-blind, prospective randomized clinical trial. Its results showed that microdosed intra-incisional antibiotic treatment 1) significantly reduced the rate of surgical site infections (SSI), 2) reduced the use of postoperative systemic antibiotics, and 3) was safe and well-tolerated. The authors recommended the routine adoption of intra-incisional microdosed antibiotics for patients undergoing skin cancer surgery.
pilocide™ surgical prophylaxis
Oral and Intraincisional Antibiotic Prophylaxis in Mohs Surgery: A Systemic Review and Meta-Analysis
Dermatol. Surg. | Volume 46 Issue 4 | 558-560 | April 2020
Summary: Antibiotic prophylaxis is used to prevent surgical site infections (SSIs) that can cause significant morbidity from pain, delayed wound healing, and impaired cosmesis. This novel meta-analysis assessed whether oral and intra-incisional antibiotics significantly improved SSI. Five randomized controlled trials with 2,919 patients receiving Mohs micrographic surgery (MMS) met the inclusion criteria for the study. The meta-analysis showed a significant reduction in SSI after intra-incisional antibiotic prophylaxis compared with placebo in the pooled analysis. Thus, this study indicated that intra-incisional antibiotic prophylaxis may be a viable prophylactic option.
pilocide™ surgical prophylaxis
A comparative study of preoperative intra-incisional infiltration of ceftriaxone vs. intravenous ceftriaxone for prevention of surgical site infections
Int. Surg. J. | Volume 6, Issue 5 | 1686-1692 | May 2019
Summary: Surgical site infection (SSI) continues to be a significant cause of post-operative morbidity and mortality. This study evaluated the effectiveness of preoperative intra-incisional infiltration of ceftriaxone for preventing SSI. Sixty patients received the control (intravenous ceftriaxone in a single dose), and sixty received intra-incisional ceftriaxone before starting the operative procedure. In the control group, 25% developed SSI, while in the treatment group, 5% developed SSI. The mean hospital stay of patients who developed SSI was nearly two times higher than those who didn't develop SSI. This study confirmed that the preoperative intra-incisional injection of ceftriaxone reduced SSI rates in all classes of wounds both clinically and statistically.
pilocide™ surgical prophylaxis
Pre-operative Intra-Incisional Antibiotic Infiltration and Prophylactic Intravenous Antibiotic Administration For Reducing Surgical Site Infection.
JAMP | Volume 5, Issue 4 | 1024-1028 | 2023
Summary: Surgical site infection (SSI) remains a significant cause of nosocomial morbidity and mortality. This comparative study assessed the efficacy of pre-operative intra-incisional ceftriaxone antibiotic in conjunction with intravenous antibiotic therapy (treatment) versus prophylactic ceftriaxone intravenous antibiotic therapy (control) in reducing surgical site infection in patients undergoing elective or emergency laparotomy surgeries. A statistically significant result of post-operative SSI was noted in 12 cases in the treatment group as compared to 29 in the control group. And a statistically significant result was noted when the wound was classified as dirty.